Timothy H. Click, PhD

Assistant Professor of Chemistry
Assistant Professor of Biochemistry

School of Arts & Sciences

About Me

I am a computational biochemist by training. I have studied proteins, DNA, and carbohydrates, along with some drug modeling. I have lived in several states and lived in Taiwan for six years. I have taught biochemistry, organic chemistry, and general chemistry to non-majors. I have taught myself Python, which is useful in my field. In my free time, I enjoy reading, programming, listening to podcasts, and spending time with my wife.

Why I’m At Mary

I chose the University of Mary because of its holistic approach to education. Students receive a great liberal arts education while deepening their faith, and as a faculty member, I can integrate my faith into my teaching. Mary offers a truly Catholic education, and the benedictine values permeate the life and culture on campus as we prepare students for life.

Expertise

My scientific expertise is in computational biochemistry. I use molecular modeling simulations to understand the allosteric communication within a protein. I use various modeling software in combination with analysis tools written in Python. I am continuing to update a software package that I initially wrote while working in Taiwan.

Raj, N., Click, T., Yang, H., Chu, J.-W. “Structure-Mechanics Statistical Learning Uncovers Mechanical Relay in Proteins.” Chem. Sci. 13, 3688¬–3696 (2022)

Weaver, T. M., Click, T. H., Khoang, T. M., Washington, T. M., Agarwal, P. K., Freudenthal, B. D.. “Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.” Nature Comm 1–12 (2022)

Raj, N., Click, T., Yang, H., Chu, J.-W. “Mechanical couplings of protein backbone and side chains exhibit scale-free network properties and specific hotspots for function.” Comput Struct Biotechnology J, 19, 5309–5320 (2021)

Phonephakdy, A. and Click, T. H. “Improving the Benefits of Psychedelic Drugs against Depression.” Excellence Event, Briar Cliff University, Sioux City, IA (2023)

Raj, N.; Click, T. H.; Chu, J.-W. ”Elucidation of the Molecular Mechanism of Protein Allostery in Cell Death Related Nuclease (CRN4) using Fluctuogram Analysis”, The Seventh Asia-Pacific Conference of Theoretical and Computational Chemistry, Kaohsiung, Taiwan (2016)

Education

PhD (Chemistry): University of Oklahoma, 2007
BS (Biology): Northwestern Oklahoma State University, 2001
BS (Chemistry): Northwestern Oklahoma State University, 2000